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P70428

Exostosin-2 (P70428)

Uniprot ID P70428
Protein Name Exostosin-2
Gene Name Ext2
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.623
Function Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan. .
GO - Molecular function
  • acetylglucosaminyltransferase activity : IDA:BHF-UCL
  • glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity : IC:BHF-UCL
  • glucuronosyltransferase activity : IDA:BHF-UCL
  • heparan sulfate N-acetylglucosaminyltransferase activity : IC:BHF-UCL
  • metal ion binding : IEA:UniProtKB-KW
  • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity : IC:BHF-UCL
  • protein heterodimerization activity : ISO:MGI
  • protein homodimerization activity : IDA:BHF-UCL
  • transferase activity, transferring glycosyl groups : ISO:MGI
GO - Biological process
  • cell differentiation : IMP:MGI
  • cellular polysaccharide biosynthetic process : ISO:MGI
  • glycosaminoglycan biosynthetic process : ISO:MGI
  • heparan sulfate proteoglycan biosynthetic process : IMP:MGI
  • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process : ISO:MGI
  • mesoderm formation : IMP:MGI
  • ossification : ISO:MGI
  • protein glycosylation : IEA:UniProtKB-UniPathway
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.