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P70399

TP53-binding protein 1 (P70399)

Uniprot ID P70399
Protein Name TP53-binding protein 1
Gene Name Tp53bp1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:15159415, PubMed:15077110, PubMed:20453858, PubMed:23333305, PubMed:26308889, PubMed:20362325). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:23333305, PubMed:20362325). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites. Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites. Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:15159415, PubMed:15077110). Participates to the repair and the orientation of the broken DNA ends during CSR (PubMed:26308889). In contrast, it is not required for classic NHEJ and V(D)J recombination (PubMed:15159415). Promotes NHEJ of dysfunctional telomeres (By similarity). .
GO - Molecular function
  • damaged DNA binding : IDA:MGI
  • methylated histone binding : IDA:UniProtKB
  • p53 binding : ISO:MGI
  • RNA polymerase II activating transcription factor binding : ISO:MGI
  • RNA polymerase II transcription cofactor activity : ISO:MGI
  • sequence-specific DNA binding : IDA:MGI
  • telomeric DNA binding : IDA:MGI
  • transcription factor binding : TAS:MGI
  • ubiquitin modification-dependent histone binding : ISS:UniProtKB
GO - Biological process
  • cellular response to DNA damage stimulus : ISO:MGI
  • cellular response to X-ray : IEA:Ensembl
  • DNA damage checkpoint : IBA:GO_Central
  • DNA repair : IDA:MGI
  • double-strand break repair via nonhomologous end joining : IDA:UniProtKB
  • negative regulation of double-strand break repair via homologous recombination : IDA:UniProtKB
  • positive regulation of isotype switching : IMP:UniProtKB
  • positive regulation of transcription by RNA polymerase II : ISO:MGI
  • protein homooligomerization : ISS:UniProtKB
  • regulation of transcription, DNA-templated : TAS:MGI
  • transcription, DNA-templated : IEA:UniProtKB-KW
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.