| Signal peptide(a) |
N |
Secretome P(b) |
0.699 |
| Function |
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. . |
| GO - Molecular function |
- ATP binding : IEA:UniProtKB-KW
- transcription coactivator activity : ISS:UniProtKB
- ubiquitin conjugating enzyme activity : IDA:MGI
- ubiquitin protein ligase binding : ISO:MGI
- ubiquitin-protein transferase activator activity : ISO:MGI
- ubiquitin-protein transferase activity : ISS:UniProtKB
|
| GO - Biological process |
- cell cycle phase transition : ISS:UniProtKB
- cell proliferation : ISS:UniProtKB
- cellular response to glucocorticoid stimulus : ISS:UniProtKB
- cellular response to steroid hormone stimulus : ISS:UniProtKB
- positive regulation of protein ubiquitination : ISO:MGI
- positive regulation of ubiquitin-protein transferase activity : ISO:MGI
- protein K11-linked ubiquitination : ISS:UniProtKB
- protein polyubiquitination : ISS:UniProtKB
- protein ubiquitination : ISS:UniProtKB
- regulation of transcription, DNA-templated : ISS:UniProtKB
- transcription, DNA-templated : IEA:UniProtKB-KW
- ubiquitin-dependent protein catabolic process : IMP:MGI
|