| Signal peptide(a) |
Y |
Secretome P(b) |
0.453 |
| Function |
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Binds to cell-surface target proteins via their chondroitin sulfate groups. Down-regulates PTPRZ1 activity. . |
| GO - Molecular function |
- chondroitin sulfate binding : ISS:UniProtKB
- chondroitin sulfate proteoglycan binding : ISO:MGI
- glycosaminoglycan binding : ISO:MGI
- growth factor activity : ISS:UniProtKB
- heparan sulfate binding : ISO:MGI
- heparin binding : ISS:UniProtKB
- protein kinase binding : ISO:MGI
- proteoglycan binding : ISO:MGI
- vascular endothelial growth factor binding : ISO:MGI
|
| GO - Biological process |
- bone mineralization : IDA:MGI
- cellular response to hypoxia : IEA:Ensembl
- cellular response to platelet-derived growth factor stimulus : IEA:Ensembl
- cellular response to UV : IEA:Ensembl
- cellular response to vitamin D : IEA:Ensembl
- cerebellum development : IEA:Ensembl
- endothelial cell differentiation : IEA:Ensembl
- estrous cycle : IEA:Ensembl
- heart development : IEA:Ensembl
- learning : IMP:MGI
- liver development : IEA:Ensembl
- long-term synaptic potentiation : IEA:Ensembl
- lung development : IEA:Ensembl
- negative regulation of angiogenesis : ISO:MGI
- negative regulation of cell migration : ISO:MGI
- negative regulation of epithelial cell proliferation : ISO:MGI
- negative regulation of glial cell proliferation : ISO:MGI
- negative regulation of membrane potential : ISO:MGI
- negative regulation of mesenchymal cell proliferation : ISO:MGI
- negative regulation of neuromuscular junction development : ISO:MGI
- ossification : IDA:MGI
- positive regulation of apoptotic process : ISO:MGI
- positive regulation of cell division : IEA:UniProtKB-KW
- positive regulation of cell proliferation : ISS:UniProtKB
- positive regulation of cell-substrate adhesion : ISO:MGI
- positive regulation of hepatocyte proliferation : ISO:MGI
- positive regulation of neuron projection development : ISO:MGI
- positive regulation of skeletal muscle acetylcholine-gated channel clustering : ISO:MGI
- regulation of cell shape : ISO:MGI
- response to activity : IEA:Ensembl
- response to ciliary neurotrophic factor : IEA:Ensembl
- response to estradiol : IEA:Ensembl
- response to kainic acid : IEA:Ensembl
- response to nerve growth factor : IEA:Ensembl
- response to progesterone : IEA:Ensembl
- retinal rod cell differentiation : ISO:MGI
- rod bipolar cell differentiation : IEA:Ensembl
- spinal cord development : IEA:Ensembl
- thalamus development : IEA:Ensembl
|