| Signal peptide(a) |
N |
Secretome P(b) |
0.77 |
| Function |
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. . |
| GO - Molecular function |
- activin binding : IPI:BHF-UCL
- FK506 binding : IDA:BHF-UCL
- ion channel binding : ISS:BHF-UCL
- macrolide binding : NAS:BHF-UCL
- peptidyl-prolyl cis-trans isomerase activity : IDA:BHF-UCL
- SMAD binding : IPI:BHF-UCL
- transforming growth factor beta receptor binding : ISS:BHF-UCL
- type I transforming growth factor beta receptor binding : ISS:BHF-UCL
|
| GO - Biological process |
- 'de novo' protein folding : TAS:BHF-UCL
- amyloid fibril formation : IDA:BHF-UCL
- calcium ion transmembrane transport : NAS:BHF-UCL
- chaperone-mediated protein folding : IBA:GO_Central
- heart morphogenesis : ISS:BHF-UCL
- heart trabecula formation : ISS:BHF-UCL
- negative regulation of phosphoprotein phosphatase activity : IDA:BHF-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling : HMP:UniProtKB
- positive regulation of protein binding : IDA:BHF-UCL
- positive regulation of protein ubiquitination : IDA:BHF-UCL
- protein folding : NAS:UniProtKB
- protein maturation by protein folding : TAS:BHF-UCL
- protein peptidyl-prolyl isomerization : IDA:BHF-UCL
- protein refolding : TAS:BHF-UCL
- regulation of activin receptor signaling pathway : IDA:BHF-UCL
- regulation of amyloid precursor protein catabolic process : IGI:ParkinsonsUK-UCL
- regulation of immune response : IMP:BHF-UCL
- regulation of protein localization : IGI:ParkinsonsUK-UCL
- regulation of ryanodine-sensitive calcium-release channel activity : IDA:BHF-UCL
- SMAD protein complex assembly : IDA:BHF-UCL
- supramolecular fiber organization : IDA:BHF-UCL
- T cell activation : NAS:BHF-UCL
- ventricular cardiac muscle tissue morphogenesis : ISS:BHF-UCL
|