| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. . |
| GO - Molecular function |
- GDP binding : IBA:GO_Central
- GTP binding : IDA:RGD
- GTPase activity : ISO:RGD
- protein-containing complex binding : ISO:RGD
- Rap guanyl-nucleotide exchange factor activity : IMP:UniProtKB
- Ras GTPase binding : ISO:RGD
|
| GO - Biological process |
- cellular response to cAMP : IEP:RGD
- cellular response to drug : IDA:RGD
- cellular response to nerve growth factor stimulus : IDA:UniProtKB
- cellular response to organic cyclic compound : IDA:RGD
- establishment of endothelial barrier : ISS:UniProtKB
- liver regeneration : IEP:RGD
- negative regulation of collagen biosynthetic process : IMP:RGD
- negative regulation of synaptic vesicle exocytosis : ISO:RGD
- nerve growth factor signaling pathway : IDA:UniProtKB
- positive regulation of ERK1 and ERK2 cascade : IMP:UniProtKB
- positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis : IMP:RGD
- positive regulation of glucose import : IMP:RGD
- positive regulation of GTPase activity : IMP:UniProtKB
- positive regulation of neuron projection development : IMP:UniProtKB
- positive regulation of protein kinase activity : IMP:UniProtKB
- positive regulation of vasculogenesis : ISS:UniProtKB
- protein localization to plasma membrane : ISS:GO_Central
- Rap protein signal transduction : ISS:UniProtKB
- regulation of cell junction assembly : ISS:UniProtKB
- regulation of neurotransmitter receptor localization to postsynaptic specialization membrane : ISO:RGD
- response to antineoplastic agent : IDA:RGD
- response to carbohydrate : IEP:RGD
- small GTPase mediated signal transduction : ISO:RGD
|