| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP-and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation. . |
| GO - Molecular function |
- dynein intermediate chain binding : IDA:RGD
- GDP binding : IDA:RGD
- GTP binding : IDA:RGD
- GTPase activity : ISS:UniProtKB
- importin-alpha family protein binding : IDA:RGD
- magnesium ion binding : ISS:UniProtKB
- protein domain specific binding : IPI:RGD
- protein heterodimerization activity : ISO:RGD
- protein-containing complex binding : IPI:RGD
|
| GO - Biological process |
- actin cytoskeleton organization : ISO:RGD
- cell division : IEA:UniProtKB-KW
- cellular protein localization : ISO:RGD
- cellular protein-containing complex localization : ISO:RGD
- cellular response to mineralocorticoid stimulus : IEP:RGD
- GTP metabolic process : ISS:UniProtKB
- hippocampus development : IEP:RGD
- microtubule cytoskeleton organization : TAS:RGD
- mitotic sister chromatid segregation : ISS:UniProtKB
- nucleocytoplasmic transport : TAS:RGD
- positive regulation of protein binding : ISO:RGD
- positive regulation of protein import into nucleus : ISO:RGD
- protein export from nucleus : ISS:UniProtKB
- protein import into nucleus : ISS:UniProtKB
- protein localization to nucleolus : ISO:RGD
- regulation of protein binding : IDA:RGD
- response to organic cyclic compound : IEP:RGD
- ribosomal large subunit export from nucleus : ISO:RGD
- ribosomal small subunit export from nucleus : ISO:RGD
- ribosomal subunit export from nucleus : IBA:GO_Central
- snRNA import into nucleus : ISS:UniProtKB
- spermatid development : IEP:RGD
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