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P62804

Histone H4 (P62804)

Uniprot ID P62804
Protein Name Histone H4
Gene Name H4c2
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (1) Interactions
Signal peptide(a) N Secretome P(b)
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Osteogenic growth peptide (OGP) stimulates osteogenesis and hematopoiesis.
GO - Molecular function
  • DNA binding : IBA:GO_Central
  • protein domain specific binding : ISO:RGD
  • protein heterodimerization activity : IEA:InterPro
GO - Biological process
  • cell differentiation : IEA:UniProtKB-KW
  • DNA replication-dependent nucleosome assembly : ISO:RGD
  • DNA replication-independent nucleosome assembly : ISO:RGD
  • DNA-templated transcription, initiation : IEA:InterPro
  • multicellular organism development : IEA:UniProtKB-KW
  • negative regulation of megakaryocyte differentiation : ISO:RGD
  • nucleosome assembly : ISO:RGD
  • ossification : IEA:UniProtKB-KW
  • protein heterotetramerization : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.