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P62738

Actin, aortic smooth muscle (P62738)

Uniprot ID P62738
Protein Name Actin, aortic smooth muscle
Gene Name Acta2
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • protein kinase binding : ISO:RGD
GO - Biological process
  • glomerular mesangial cell development : ISO:RGD
  • mesenchyme migration : ISS:AgBase
  • muscle contraction : IDA:RGD
  • positive regulation of ERK1 and ERK2 cascade : IMP:RGD
  • positive regulation of gene expression : ISS:AgBase
  • positive regulation of hepatic stellate cell activation : IMP:RGD
  • positive regulation of hepatic stellate cell contraction : IMP:RGD
  • positive regulation of hepatic stellate cell migration : IMP:RGD
  • regulation of blood pressure : ISO:RGD
  • regulation of wound healing : IMP:RGD
  • response to virus : ISO:RGD
  • vascular smooth muscle contraction : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.