Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P62260

14-3-3 protein epsilon (P62260)

Uniprot ID P62260
Protein Name 14-3-3 protein epsilon
Gene Name Ywhae
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (2) Interactions
Signal peptide(a) N Secretome P(b)
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. .
GO - Molecular function
  • calcium channel regulator activity : ISO:RGD
  • enzyme binding : IPI:RGD
  • histone deacetylase binding : ISO:RGD
  • identical protein binding : ISO:RGD
  • ion channel binding : ISO:RGD
  • phosphoprotein binding : ISO:RGD
  • phosphoserine residue binding : ISO:RGD
  • potassium channel regulator activity : ISO:RGD
  • protein domain specific binding : ISO:RGD
  • protein heterodimerization activity : ISO:RGD
  • protein kinase C inhibitor activity : TAS:RGD
  • protein phosphatase binding : ISO:RGD
  • protein-containing complex binding : IPI:RGD
  • scaffold protein binding : ISO:RGD
  • ubiquitin protein ligase binding : ISO:RGD
GO - Biological process
  • cellular response to heat : ISS:UniProtKB
  • cerebral cortex development : ISO:RGD
  • hippocampus development : ISO:RGD
  • MAPK cascade : ISS:UniProtKB
  • negative regulation of calcium ion export across plasma membrane : ISO:RGD
  • negative regulation of calcium ion transmembrane transporter activity : ISO:RGD
  • negative regulation of peptidyl-serine dephosphorylation : ISO:RGD
  • negative regulation of protein dephosphorylation : ISO:RGD
  • neuron migration : ISO:RGD
  • positive regulation of protein export from nucleus : ISS:UniProtKB
  • protein localization to nucleus : ISS:UniProtKB
  • protein targeting : ISO:RGD
  • regulation of cytosolic calcium ion concentration : ISO:RGD
  • regulation of membrane repolarization : ISO:RGD
  • regulation of postsynaptic membrane neurotransmitter receptor levels : IDA:SynGO
  • regulation of potassium ion transmembrane transporter activity : ISO:RGD
  • signal transduction : TAS:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.