14-3-3 protein epsilon (P62259)

Uniprot ID P62259
Protein Name 14-3-3 protein epsilon
Gene Name Ywhae
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.67
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. .
GO - Molecular function
  • cadherin binding : ISO:MGI
  • calcium channel regulator activity : ISO:MGI
  • enzyme binding : ISO:MGI
  • histone deacetylase binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • ion channel binding : ISO:MGI
  • phosphoprotein binding : ISO:MGI
  • phosphoserine residue binding : ISO:MGI
  • potassium channel regulator activity : ISO:MGI
  • protein domain specific binding : IDA:MGI
  • protein heterodimerization activity : ISO:MGI
  • protein-containing complex binding : ISO:MGI
  • scaffold protein binding : ISO:MGI
  • ubiquitin protein ligase binding : ISO:MGI
GO - Biological process
  • cellular response to heat : ISS:UniProtKB
  • cerebral cortex development : IMP:MGI
  • hippocampus development : IMP:MGI
  • MAPK cascade : ISS:UniProtKB
  • negative regulation of calcium ion export across plasma membrane : ISO:MGI
  • negative regulation of calcium ion transmembrane transporter activity : ISO:MGI
  • negative regulation of peptidyl-serine dephosphorylation : ISO:MGI
  • negative regulation of protein dephosphorylation : IDA:MGI
  • neuron migration : IMP:MGI
  • positive regulation of protein export from nucleus : ISS:UniProtKB
  • protein targeting : IDA:MGI
  • regulation of cytosolic calcium ion concentration : ISO:MGI
  • regulation of membrane repolarization : ISO:MGI
  • regulation of potassium ion transmembrane transporter activity : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.