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P61983

14-3-3 protein gamma (P61983)

Uniprot ID P61983
Protein Name 14-3-3 protein gamma
Gene Name Ywhag
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) N Secretome P(b)
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
GO - Molecular function
  • actin binding : ISS:UniProtKB
  • enzyme regulator activity : TAS:RGD
  • identical protein binding : ISO:RGD
  • insulin-like growth factor receptor binding : ISS:UniProtKB
  • protein domain specific binding : ISO:RGD
  • protein kinase C binding : ISS:UniProtKB
  • receptor tyrosine kinase binding : IPI:RGD
GO - Biological process
  • cellular response to insulin stimulus : IDA:RGD
  • protein targeting : ISO:RGD
  • regulation of neuron differentiation : ISS:UniProtKB
  • regulation of synaptic plasticity : ISS:UniProtKB
  • signal transduction : TAS:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.