Heterogeneous nuclear ribonucleoprotein K (P61980)

Uniprot ID	P61980
Protein Name	Heterogeneous nuclear ribonucleoprotein K
Gene Name	Hnrnpk
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)
Function	One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). .
GO - Molecular function	actinin binding : IPI:RGD ATPase binding : IPI:RGD C-rich single-stranded DNA binding : IDA:RGD cis-regulatory region sequence-specific DNA binding : IDA:RGD DNA-binding transcription activator activity, RNA polymerase II-specific : ISO:RGD double-stranded DNA binding : IDA:RGD heat shock protein binding : IPI:RGD identical protein binding : ISO:RGD lamin binding : IPI:RGD mRNA 3'-UTR binding : IDA:RGD mRNA CDS binding : IDA:RGD pre-mRNA 3'-splice site binding : IDA:RGD protein domain specific binding : IPI:RGD ribonucleoprotein complex binding : IDA:RGD RNA binding : ISO:RGD RNA polymerase II cis-regulatory region sequence-specific DNA binding : ISO:RGD single-stranded DNA binding : IDA:RGD transcription factor binding : IPI:RGD
GO - Biological process	acute-phase response : IEP:RGD aging : IEP:RGD camera-type eye development : IEP:RGD cellular response to amino acid stimulus : IEP:RGD cellular response to forskolin : IDA:RGD cellular response to glucose stimulus : IEP:RGD cellular response to insulin stimulus : IDA:RGD cellular response to rapamycin : IEP:RGD central nervous system development : IEP:RGD cerebellum development : IEP:RGD cerebral cortex development : IDA:RGD hippocampus development : IEP:RGD kidney development : IEP:RGD liver development : IEP:RGD lung development : IEP:RGD modulation of chemical synaptic transmission : IMP:SynGO mRNA processing : IEA:UniProtKB-KW negative regulation of apoptotic process : IMP:RGD negative regulation of branching morphogenesis of a nerve : IMP:RGD negative regulation of gene expression : IMP:RGD negative regulation of mRNA splicing, via spliceosome : ISO:RGD negative regulation of protein binding : IMP:RGD negative regulation of transcription by RNA polymerase II : IMP:RGD ovarian follicle development : IMP:RGD peripheral nervous system development : IEP:RGD positive regulation of dendrite extension : IMP:RGD positive regulation of dendritic spine development : IMP:RGD positive regulation of long-term synaptic potentiation : IMP:RGD positive regulation of low-density lipoprotein particle receptor biosynthetic process : ISO:RGD positive regulation of neuron projection development : IMP:RGD positive regulation of protein localization to cell surface : IMP:RGD positive regulation of receptor-mediated endocytosis : ISO:RGD positive regulation of RNA splicing : IMP:RGD positive regulation of synapse maturation : IMP:RGD positive regulation of synaptic transmission : IMP:RGD positive regulation of transcription by RNA polymerase II : ISO:RGD regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : ISO:RGD regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter : ISO:RGD regulation of low-density lipoprotein particle clearance : ISO:RGD regulation of postsynapse organization : IDA:SynGO regulation of transcription by RNA polymerase II : IMP:RGD response to activity : IEP:RGD response to salt : IEP:RGD RNA splicing : IEA:UniProtKB-KW thymus development : IEP:RGD

Back

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}