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P61972

Nuclear transport factor 2 (P61972)

Uniprot ID P61972
Protein Name Nuclear transport factor 2
Gene Name Nutf2
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. .
GO - Molecular function
  • identical protein binding : ISO:RGD
  • nuclear import signal receptor activity : IDA:UniProtKB
  • Ran GTPase binding : IPI:UniProtKB
  • structural constituent of nuclear pore : ISO:RGD
GO - Biological process
  • mRNA transport : IEA:UniProtKB-KW
  • negative regulation of vascular endothelial growth factor production : IMP:RGD
  • nucleocytoplasmic transport : IBA:GO_Central
  • positive regulation of protein import into nucleus : IMP:RGD
  • protein export from nucleus : ISO:RGD
  • protein import into nucleus : IMP:UniProtKB
  • protein localization to nuclear pore : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.