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P61916

NPC intracellular cholesterol transporter 2 (P61916)

Uniprot ID P61916
Protein Name NPC intracellular cholesterol transporter 2
Gene Name NPC2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.942
Function Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:17018531, PubMed:11125141, PubMed:18772377, PubMed:29580834, PubMed:15937921). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity). .
GO - Molecular function
  • cholesterol binding : IDA:UniProtKB
  • cholesterol transfer activity : IDA:BHF-UCL
  • enzyme binding : IPI:UniProtKB
  • sterol binding : IBA:GO_Central
GO - Biological process
  • cholesterol efflux : IDA:BHF-UCL
  • cholesterol homeostasis : IDA:UniProtKB
  • cholesterol metabolic process : IEA:UniProtKB-KW
  • cholesterol transport : IDA:UniProtKB
  • glycolipid transport : TAS:HGNC-UCL
  • intracellular cholesterol transport : IDA:UniProtKB
  • intracellular sterol transport : IDA:HGNC-UCL
  • low-density lipoprotein particle clearance : TAS:Reactome
  • neutrophil degranulation : TAS:Reactome
  • phospholipid transport : TAS:HGNC-UCL
  • regulation of isoprenoid metabolic process : TAS:UniProtKB
  • response to virus : IEP:UniProtKB
  • sterol transport : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.