Signal peptide(a) |
N |
Secretome P(b) |
0.72 |
Function |
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination-and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity). . |
GO - Molecular function |
- endopeptidase activator activity : ISO:MGI
- identical protein binding : ISO:MGI
- MDM2/MDM4 family protein binding : ISS:UniProtKB
- p53 binding : ISS:UniProtKB
|
GO - Biological process |
- apoptotic process : IEA:UniProtKB-KW
- cell cycle : IEA:UniProtKB-KW
- negative regulation of extrinsic apoptotic signaling pathway : ISS:UniProtKB
- positive regulation of endopeptidase activity : IBA:GO_Central
- regulation of G1/S transition of mitotic cell cycle : IBA:GO_Central
- regulation of proteasomal protein catabolic process : ISO:MGI
|