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P61289

Proteasome activator complex subunit 3 (P61289)

Uniprot ID P61289
Protein Name Proteasome activator complex subunit 3
Gene Name PSME3
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.629
Function Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination-and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). .
GO - Molecular function
  • endopeptidase activator activity : IDA:UniProtKB
  • identical protein binding : IPI:IntAct
  • MDM2/MDM4 family protein binding : IDA:UniProtKB
  • p53 binding : IDA:UniProtKB
GO - Biological process
  • apoptotic process : IEA:UniProtKB-KW
  • cell cycle : IEA:UniProtKB-KW
  • negative regulation of extrinsic apoptotic signaling pathway : IDA:UniProtKB
  • post-translational protein modification : TAS:Reactome
  • protein deubiquitination : TAS:Reactome
  • regulation of G1/S transition of mitotic cell cycle : IBA:GO_Central
  • regulation of proteasomal protein catabolic process : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.