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P61081

NEDD8-conjugating enzyme Ubc12 (P61081)

Uniprot ID P61081
Protein Name NEDD8-conjugating enzyme Ubc12
Gene Name UBE2M
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.808
Function Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • NEDD8 transferase activity : IDA:UniProtKB
  • ubiquitin-protein transferase activity : IMP:UniProtKB
GO - Biological process
  • cellular protein modification process : IMP:UniProtKB
  • positive regulation of neuron apoptotic process : IEA:Ensembl
  • post-translational protein modification : TAS:Reactome
  • protein neddylation : IDA:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.