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P60201

Myelin proteolipid protein (P60201)

Uniprot ID P60201
Protein Name Myelin proteolipid protein
Gene Name PLP1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
GO - Molecular function
  • identical protein binding : IPI:IntAct
  • structural constituent of myelin sheath : IEA:Ensembl
  • structural molecule activity : TAS:ProtInc
GO - Biological process
  • astrocyte development : IEA:Ensembl
  • axon development : IEA:Ensembl
  • axon ensheathment : TAS:ProtInc
  • cell maturation : IEA:Ensembl
  • central nervous system myelination : IEA:Ensembl
  • chemical synaptic transmission : TAS:ProtInc
  • inflammatory response : IEA:Ensembl
  • integrin-mediated signaling pathway : IEA:Ensembl
  • long-chain fatty acid biosynthetic process : IEA:Ensembl
  • positive regulation of gene expression : IEA:Ensembl
  • substantia nigra development : HEP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.