Neurexin-1-beta (P58400)

Uniprot ID P58400
Protein Name Neurexin-1-beta
Gene Name NRXN1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.162
Function Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). .
GO - Molecular function
  • calcium-dependent protein binding : ISS:BHF-UCL
  • cell adhesion molecule binding : ISS:BHF-UCL
  • metal ion binding : IEA:UniProtKB-KW
  • neuroligin family protein binding : ISS:ARUK-UCL
  • signaling receptor binding : ISS:BHF-UCL
  • transmembrane signaling receptor activity : ISS:BHF-UCL
  • type 1 fibroblast growth factor receptor binding : IDA:ARUK-UCL
GO - Biological process
  • adult behavior : IMP:BHF-UCL
  • angiogenesis : ISS:UniProtKB
  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules : ISS:BHF-UCL
  • cellular response to calcium ion : ISS:ARUK-UCL
  • cerebellar granule cell differentiation : ISS:BHF-UCL
  • establishment of protein localization : ISS:BHF-UCL
  • gamma-aminobutyric acid receptor clustering : ISS:BHF-UCL
  • gephyrin clustering involved in postsynaptic density assembly : ISS:BHF-UCL
  • guanylate kinase-associated protein clustering : ISS:BHF-UCL
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : ISS:BHF-UCL
  • learning : IMP:BHF-UCL
  • negative regulation of filopodium assembly : ISS:BHF-UCL
  • negative regulation of gene expression : IDA:ARUK-UCL
  • neuroligin clustering involved in postsynaptic membrane assembly : ISS:BHF-UCL
  • neuron cell-cell adhesion : ISS:BHF-UCL
  • neuron projection development : IGI:ARUK-UCL
  • neuronal signal transduction : TAS:BHF-UCL
  • NMDA glutamate receptor clustering : ISS:BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade : IDA:ARUK-UCL
  • positive regulation of excitatory postsynaptic potential : ISS:BHF-UCL
  • positive regulation of fibroblast growth factor receptor signaling pathway : IDA:ARUK-UCL
  • positive regulation of gene expression : IDA:ARUK-UCL
  • positive regulation of peptidyl-serine phosphorylation : IDA:ARUK-UCL
  • positive regulation of presynaptic active zone assembly : TAS:BHF-UCL
  • positive regulation of protein kinase A signaling : IDA:ARUK-UCL
  • positive regulation of protein kinase B signaling : IDA:ARUK-UCL
  • positive regulation of protein kinase C activity : IDA:ARUK-UCL
  • positive regulation of protein localization to plasma membrane : ISS:BHF-UCL
  • positive regulation of synapse assembly : TAS:BHF-UCL
  • positive regulation of synaptic transmission, glutamatergic : ISS:BHF-UCL
  • postsynaptic density protein 95 clustering : ISS:BHF-UCL
  • postsynaptic membrane assembly : ISS:BHF-UCL
  • presynaptic membrane assembly : ISS:BHF-UCL
  • protein localization to synapse : ISS:BHF-UCL
  • protein-containing complex assembly involved in synapse maturation : ISS:BHF-UCL
  • receptor localization to synapse : ISS:BHF-UCL
  • regulation of AMPA receptor activity : ISS:BHF-UCL
  • regulation of NMDA receptor activity : ISS:BHF-UCL
  • signal transduction : ISS:BHF-UCL
  • social behavior : IMP:BHF-UCL
  • synapse assembly : ISS:BHF-UCL
  • synaptic vesicle clustering : ISS:BHF-UCL
  • vocalization behavior : IMP:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.