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P54826

Growth arrest-specific protein 1 (P54826)

Uniprot ID P54826
Protein Name Growth arrest-specific protein 1
Gene Name GAS1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.163
Function Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. .
GO - Molecular function
GO - Biological process
  • cell cycle arrest : IEA:UniProtKB-KW
  • cell fate commitment : ISS:UniProtKB
  • cellular response to vascular endothelial growth factor stimulus : IEP:UniProtKB
  • developmental growth : ISS:UniProtKB
  • negative regulation of mitotic cell cycle : IDA:UniProtKB
  • negative regulation of protein processing : IMP:UniProtKB
  • regulation of apoptotic process : ISS:UniProtKB
  • regulation of ER to Golgi vesicle-mediated transport : IMP:UniProtKB
  • regulation of smoothened signaling pathway : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.