Galactocerebrosidase (P54818)

Uniprot ID P54818
Protein Name Galactocerebrosidase
Gene Name Galc
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.703
Function Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. .
GO - Molecular function
  • galactosylceramidase activity : IDA:UniProtKB
GO - Biological process
  • galactosylceramide catabolic process : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.