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P54760

Ephrin type-B receptor 4 (P54760)

Uniprot ID P54760
Protein Name Ephrin type-B receptor 4
Gene Name EPHB4
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.215
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • ephrin receptor activity : IDA:UniProtKB
  • protein tyrosine kinase activity : EXP:Reactome
  • transmembrane receptor protein tyrosine kinase activity : IDA:UniProtKB
GO - Biological process
  • angiogenesis : ISS:UniProtKB
  • cell adhesion : IDA:UniProtKB
  • cell migration involved in sprouting angiogenesis : IDA:UniProtKB
  • ephrin receptor signaling pathway : IDA:UniProtKB
  • heart morphogenesis : ISS:UniProtKB
  • protein autophosphorylation : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.