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P54311

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (P54311)

Uniprot ID P54311
Protein Name Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Gene Name Gnb1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
GO - Molecular function
  • alkylglycerophosphoethanolamine phosphodiesterase activity : IDA:MGI
  • GTPase activity : ISO:RGD
  • GTPase binding : ISO:RGD
  • protein-containing complex binding : ISO:RGD
  • spectrin binding : IDA:MGI
GO - Biological process
  • cardiac muscle cell apoptotic process : IDA:MGI
  • cell population proliferation : ISO:RGD
  • cellular response to hypoxia : IDA:MGI
  • G protein-coupled receptor signaling pathway : IMP:RGD
  • phospholipase C-activating G protein-coupled receptor signaling pathway : ISO:RGD
  • positive regulation of cytosolic calcium ion concentration : IMP:RGD
  • retina development in camera-type eye : ISO:RGD
  • sensory perception of taste : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.