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P54001

Prolyl 4-hydroxylase subunit alpha-1 (P54001)

Uniprot ID P54001
Protein Name Prolyl 4-hydroxylase subunit alpha-1
Gene Name P4ha1
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.723
Function Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens and other proteins. .
GO - Molecular function
  • identical protein binding : ISO:RGD
  • iron ion binding : IEA:InterPro
  • L-ascorbic acid binding : IEA:UniProtKB-KW
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen : IEA:InterPro
  • procollagen-proline 4-dioxygenase activity : ISO:RGD
GO - Biological process
  • collagen fibril organization : ISO:RGD
  • peptidyl-proline hydroxylation to 4-hydroxy-L-proline : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.