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P53813

Vitamin K-dependent protein S (P53813)

Uniprot ID P53813
Protein Name Vitamin K-dependent protein S
Gene Name Pros1
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • protein-containing complex binding : IDA:RGD
GO - Biological process
  • blood coagulation : IEA:UniProtKB-KW
  • fibrinolysis : IEA:UniProtKB-KW
  • liver development : IEP:RGD
  • negative regulation of coagulation : IDA:RGD
  • positive regulation of phagocytosis : IDA:RGD
  • response to lipopolysaccharide : IEP:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.