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P52888

Thimet oligopeptidase (P52888)

Uniprot ID P52888
Protein Name Thimet oligopeptidase
Gene Name THOP1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.517
Function Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • metalloendopeptidase activity : IBA:GO_Central
  • peptide binding : IEA:Ensembl
GO - Biological process
  • peptide metabolic process : IBA:GO_Central
  • protein polyubiquitination : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.