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P52799

Ephrin-B2 (P52799)

Uniprot ID P52799
Protein Name Ephrin-B2
Gene Name EFNB2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.17
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. .(Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.
GO - Molecular function
  • ephrin receptor binding : IPI:UniProtKB
  • virus receptor activity : IEA:UniProtKB-KW
GO - Biological process
  • adherens junction organization : IEA:Ensembl
  • anatomical structure morphogenesis : TAS:ProtInc
  • animal organ morphogenesis : IEA:Ensembl
  • axon guidance : IBA:GO_Central
  • blood vessel morphogenesis : IBA:GO_Central
  • cell adhesion : IDA:UniProtKB
  • cell migration involved in sprouting angiogenesis : IDA:UniProtKB
  • cell-cell signaling : TAS:ProtInc
  • ephrin receptor signaling pathway : IDA:UniProtKB
  • lymph vessel development : IEA:Ensembl
  • negative regulation of keratinocyte proliferation : IEA:Ensembl
  • negative regulation of neuron projection development : IDA:ARUK-UCL
  • nephric duct morphogenesis : IEA:Ensembl
  • positive regulation of aorta morphogenesis : IEA:Ensembl
  • positive regulation of cardiac muscle cell differentiation : ISS:BHF-UCL
  • positive regulation of cell population proliferation : IMP:BHF-UCL
  • positive regulation of neuron death : IDA:ARUK-UCL
  • presynapse assembly : IEA:Ensembl
  • regulation of chemotaxis : IDA:UniProtKB
  • regulation of postsynaptic membrane neurotransmitter receptor levels : IEA:Ensembl
  • regulation of postsynaptic neurotransmitter receptor internalization : IEA:Ensembl
  • T cell costimulation : IEA:Ensembl
  • venous blood vessel morphogenesis : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.