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P52796

Ephrin-B1 (P52796)

Uniprot ID P52796
Protein Name Ephrin-B1
Gene Name Efnb1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b)
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:7936648). Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells (By similarity). Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:7936648). Can also bind EPHB2 and EPHB3 (By similarity). Binds to, and induces the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). .
GO - Molecular function
  • ephrin receptor binding : ISO:RGD
GO - Biological process
  • axon guidance : ISO:RGD
  • embryonic pattern specification : ISO:RGD
  • ephrin receptor signaling pathway : IBA:GO_Central
  • nervous system development : IMP:RGD
  • neural crest cell migration : ISO:RGD
  • positive regulation of T cell proliferation : ISO:RGD
  • presynapse assembly : IDA:SynGO
  • T cell costimulation : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.