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P52480

Pyruvate kinase PKM (P52480)

Uniprot ID P52480
Protein Name Pyruvate kinase PKM
Gene Name Pkm
Species Mus musculus (Mouse)
Basic Information Experiments (6) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.61
Function Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity). .
GO - Molecular function
  • ADP binding : ISO:MGI
  • ATP binding : IEA:UniProtKB-KW
  • cadherin binding : ISO:MGI
  • identical protein binding : ISO:MGI
  • kinase activity : IEA:UniProtKB-KW
  • magnesium ion binding : IEA:InterPro
  • potassium ion binding : IEA:InterPro
  • pyruvate kinase activity : IDA:MGI
  • thyroid hormone binding : ISO:MGI
GO - Biological process
  • animal organ regeneration : ISO:MGI
  • ATP biosynthetic process : ISO:MGI
  • cellular response to insulin stimulus : IBA:GO_Central
  • glucose metabolic process : ISO:MGI
  • glycolytic process : IDA:MGI
  • liver development : ISO:MGI
  • programmed cell death : ISO:MGI
  • protein homotetramerization : ISO:MGI
  • pyruvate biosynthetic process : ISO:MGI
  • skeletal muscle tissue regeneration : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.