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P52434

DNA-directed RNA polymerases I, II, and III subunit RPABC3 (P52434)

Uniprot ID P52434
Protein Name DNA-directed RNA polymerases I, II, and III subunit RPABC3
Gene Name POLR2H
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.86
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. .
GO - Molecular function
  • DNA-directed 5'-3' RNA polymerase activity : IEA:UniProtKB-KW
  • single-stranded DNA binding : IDA:CAFA
GO - Biological process
  • 7-methylguanosine mRNA capping : TAS:Reactome
  • fibroblast growth factor receptor signaling pathway : TAS:Reactome
  • mRNA splicing, via spliceosome : TAS:Reactome
  • positive regulation of gene expression, epigenetic : TAS:Reactome
  • regulation of gene silencing by miRNA : TAS:Reactome
  • RNA metabolic process : TAS:Reactome
  • snRNA transcription by RNA polymerase II : TAS:Reactome
  • termination of RNA polymerase I transcription : TAS:Reactome
  • transcription by RNA polymerase II : IDA:UniProtKB
  • transcription by RNA polymerase III : IEA:GOC
  • transcription elongation from RNA polymerase II promoter : TAS:Reactome
  • transcription initiation from RNA polymerase I promoter : TAS:Reactome
  • transcription initiation from RNA polymerase II promoter : TAS:Reactome
  • transcription-coupled nucleotide-excision repair : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.