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P51911

Calponin-1 (P51911)

Uniprot ID P51911
Protein Name Calponin-1
Gene Name CNN1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.589
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). .
GO - Molecular function
  • actin binding : IEA:UniProtKB-KW
  • calmodulin binding : IEA:UniProtKB-KW
GO - Biological process
  • actomyosin structure organization : IEA:InterPro
  • negative regulation of vascular smooth muscle cell proliferation : IGI:BHF-UCL
  • regulation of smooth muscle contraction : TAS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.