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P51858

Hepatoma-derived growth factor (P51858)

Uniprot ID P51858
Protein Name Hepatoma-derived growth factor
Gene Name HDGF
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.531
Function [Isoform 1]: Acts as a transcriptional repressor (PubMed:17974029). Has mitogenic activity for fibroblasts (PubMed:11751870, PubMed:26845719). Heparin-binding protein (PubMed:15491618). .[Isoform 2]: Does not have mitogenic activity for fibroblasts (PubMed:26845719). Does not bind heparin (PubMed:26845719). {ECO:0000269|PubMed:26845719}.[Isoform 3]: Has mitogenic activity for fibroblasts (PubMed:26845719). Heparin-binding protein (PubMed:26845719). {ECO:0000269|PubMed:26845719}.
GO - Molecular function
  • actin binding : IDA:UniProtKB
  • DNA binding : IEA:UniProtKB-KW
  • growth factor activity : IEA:UniProtKB-KW
  • heparin binding : IDA:UniProtKB
  • nucleotide binding : IEA:UniProtKB-KW
  • RNA binding : HDA:UniProtKB
  • transcription corepressor activity : IDA:BHF-UCL
  • transcription corepressor binding : IPI:BHF-UCL
  • tubulin binding : IDA:UniProtKB
GO - Biological process
  • cellular response to interleukin-7 : IEA:Ensembl
  • IRE1-mediated unfolded protein response : TAS:Reactome
  • negative regulation of transcription by RNA polymerase II : IDA:BHF-UCL
  • positive regulation of cell division : IDA:UniProtKB
  • signal transduction : NAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.