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P51693

Amyloid-like protein 1 (P51693)

Uniprot ID P51693
Protein Name Amyloid-like protein 1
Gene Name APLP1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.223
Function May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. .The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. {ECO:0000250}.
GO - Molecular function
  • alpha-2A adrenergic receptor binding : IPI:BHF-UCL
  • alpha-2B adrenergic receptor binding : IPI:BHF-UCL
  • alpha-2C adrenergic receptor binding : IPI:BHF-UCL
  • heparin binding : IEA:UniProtKB-KW
  • identical protein binding : IPI:IntAct
  • transition metal ion binding : IEA:InterPro
GO - Biological process
  • animal organ morphogenesis : TAS:ProtInc
  • apoptotic process : IEA:UniProtKB-KW
  • cell adhesion : IEA:UniProtKB-KW
  • cellular response to norepinephrine stimulus : IDA:BHF-UCL
  • endocytosis : IEA:UniProtKB-KW
  • negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway : IDA:BHF-UCL
  • nervous system development : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.