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P51665

26S proteasome non-ATPase regulatory subunit 7 (P51665)

Uniprot ID P51665
Protein Name 26S proteasome non-ATPase regulatory subunit 7
Gene Name PSMD7
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.078
Function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .
GO - Molecular function
  • protein homodimerization activity : IDA:UniProtKB
GO - Biological process
  • neutrophil degranulation : TAS:Reactome
  • post-translational protein modification : TAS:Reactome
  • proteasome-mediated ubiquitin-dependent protein catabolic process : IBA:GO_Central
  • protein deubiquitination : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.