| Signal peptide(a) |
N |
Secretome P(b) |
0.522 |
| Function |
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES. Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). . |
| GO - Molecular function |
- DNA binding : ISO:MGI
- DNA binding transcription factor activity : ISO:MGI
- RNA binding : IEA:UniProtKB-KW
- ubiquitin protein ligase binding : ISO:MGI
|
| GO - Biological process |
- negative regulation of apoptotic process : ISS:UniProtKB
- negative regulation of transcription, DNA-templated : ISO:MGI
- positive regulation of cell differentiation : ISS:UniProtKB
- regulation of translation : IEA:UniProtKB-KW
- rRNA processing : IEA:UniProtKB-KW
- transcription, DNA-templated : IEA:UniProtKB-KW
|