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P50552

Vasodilator-stimulated phosphoprotein (P50552)

Uniprot ID P50552
Protein Name Vasodilator-stimulated phosphoprotein
Gene Name VASP
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.697
Function Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. .
GO - Molecular function
  • actin binding : IEA:UniProtKB-KW
  • cadherin binding : HDA:BHF-UCL
  • profilin binding : IPI:UniProtKB
  • SH3 domain binding : IEA:UniProtKB-KW
GO - Biological process
  • actin polymerization or depolymerization : IEA:InterPro
  • axon guidance : TAS:Reactome
  • cell junction assembly : TAS:Reactome
  • neural tube closure : IEA:Ensembl
  • positive regulation of actin filament polymerization : IDA:UniProtKB
  • protein homotetramerization : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.