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P50454

Serpin H1 (P50454)

Uniprot ID P50454
Protein Name Serpin H1
Gene Name SERPINH1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.693
Function Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
GO - Molecular function
  • collagen binding : NAS:UniProtKB
  • RNA binding : HDA:UniProtKB
  • serine-type endopeptidase inhibitor activity : IBA:GO_Central
  • unfolded protein binding : IEA:Ensembl
GO - Biological process
  • chondrocyte development involved in endochondral bone morphogenesis : IEA:Ensembl
  • collagen biosynthetic process : IEA:Ensembl
  • collagen fibril organization : IBA:GO_Central
  • negative regulation of endopeptidase activity : IBA:GO_Central
  • protein maturation : IEA:Ensembl
  • response to unfolded protein : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.