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P50429

Arylsulfatase B (P50429)

Uniprot ID P50429
Protein Name Arylsulfatase B
Gene Name Arsb
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). .
GO - Molecular function
  • arylsulfatase activity : IDA:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • N-acetylgalactosamine-4-sulfatase activity : ISS:UniProtKB
  • sulfuric ester hydrolase activity : ISO:MGI
GO - Biological process
  • anterior head development : IMP:MGI
  • autophagy : ISO:MGI
  • central nervous system development : ISO:MGI
  • colon epithelial cell migration : ISS:UniProtKB
  • positive regulation of neuron projection development : ISS:UniProtKB
  • regulation of epithelial cell migration : ISS:UniProtKB
  • response to estrogen : ISO:MGI
  • response to methylmercury : ISO:MGI
  • response to nutrient : ISO:MGI
  • response to pH : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.