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P50398

Rab GDP dissociation inhibitor alpha (P50398)

Uniprot ID P50398
Protein Name Rab GDP dissociation inhibitor alpha
Gene Name Gdi1
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. .
GO - Molecular function
  • GTPase activator activity : IEA:UniProtKB-KW
  • Rab GDP-dissociation inhibitor activity : IDA:RGD
  • Rab GTPase binding : IPI:UniProtKB
GO - Biological process
  • negative regulation of axonogenesis : IDA:UniProtKB
  • negative regulation of protein targeting to membrane : ISS:UniProtKB
  • positive regulation of axon extension : IMP:RGD
  • protein transport : IEA:InterPro
  • Rab protein signal transduction : ISS:UniProtKB
  • response to calcium ion : IDA:RGD
  • vesicle-mediated transport : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.