Guanine nucleotide-binding protein G(q) subunit alpha (P50148)

Uniprot ID P50148
Protein Name Guanine nucleotide-binding protein G(q) subunit alpha
Gene Name GNAQ
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.705
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). .
GO - Molecular function
  • G-protein beta/gamma-subunit complex binding : IBA:GO_Central
  • GTP binding : IEA:UniProtKB-KW
  • GTPase activator activity : IDA:UniProtKB
  • GTPase activity : TAS:ProtInc
  • metal ion binding : IEA:UniProtKB-KW
  • type 2A serotonin receptor binding : IBA:GO_Central
GO - Biological process
  • action potential : IBA:GO_Central
  • activation of phospholipase C activity : TAS:ProtInc
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway : IBA:GO_Central
  • blood coagulation : TAS:ProtInc
  • developmental pigmentation : IEA:Ensembl
  • embryonic digit morphogenesis : IEA:Ensembl
  • entrainment of circadian clock : ISS:AgBase
  • forebrain neuron development : IEA:Ensembl
  • G-protein coupled acetylcholine receptor signaling pathway : ISS:AgBase
  • G-protein coupled receptor signaling pathway : TAS:Reactome
  • glutamate receptor signaling pathway : IBA:GO_Central
  • heart development : IEA:Ensembl
  • maternal behavior : IEA:Ensembl
  • negative regulation of protein kinase activity : IMP:BHF-UCL
  • neuron remodeling : IEA:Ensembl
  • phospholipase C-activating dopamine receptor signaling pathway : IBA:GO_Central
  • phototransduction, visible light : ISS:AgBase
  • platelet activation : TAS:Reactome
  • post-embryonic development : IEA:Ensembl
  • protein stabilization : IMP:BHF-UCL
  • regulation of canonical Wnt signaling pathway : IMP:BHF-UCL
  • regulation of melanocyte differentiation : IEA:Ensembl
  • skeletal system development : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.