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P49914

5-formyltetrahydrofolate cyclo-ligase (P49914)

Uniprot ID P49914
Protein Name 5-formyltetrahydrofolate cyclo-ligase
Gene Name MTHFS
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.777
Function Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate. .
GO - Molecular function
  • 5-formyltetrahydrofolate cyclo-ligase activity : IDA:UniProtKB
  • ATP binding : IDA:BHF-UCL
  • folic acid binding : IDA:BHF-UCL
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • folic acid catabolic process : IMP:BHF-UCL
  • folic acid metabolic process : TAS:Reactome
  • folic acid-containing compound biosynthetic process : IBA:GO_Central
  • formate metabolic process : NAS:UniProtKB
  • glutamate metabolic process : IMP:BHF-UCL
  • tetrahydrofolate interconversion : IMP:BHF-UCL
  • tetrahydrofolate metabolic process : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.