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P49773

Histidine triad nucleotide-binding protein 1 (P49773)

Uniprot ID P49773
Protein Name Histidine triad nucleotide-binding protein 1
Gene Name HINT1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.879
Function Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. .
GO - Molecular function
  • hydrolase activity : IDA:UniProtKB
  • nucleotide binding : IEA:UniProtKB-KW
  • protein kinase C binding : TAS:ProtInc
GO - Biological process
  • intrinsic apoptotic signaling pathway by p53 class mediator : IMP:UniProtKB
  • positive regulation of calcium-mediated signaling : IEA:Ensembl
  • purine ribonucleotide catabolic process : IDA:UniProtKB
  • regulation of transcription, DNA-templated : IMP:UniProtKB
  • signal transduction : TAS:ProtInc
  • transcription, DNA-templated : IEA:UniProtKB-KW
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.