| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. . |
| GO - Molecular function |
- BMP receptor binding : ISO:RGD
- co-receptor binding : ISO:RGD
- cytokine activity : IBA:GO_Central
- growth factor activity : IDA:RGD
- identical protein binding : IPI:RGD
- phosphatase activator activity : ISO:RGD
- protein domain specific binding : IPI:RGD
- protein heterodimerization activity : ISO:RGD
- retinol dehydrogenase activity : ISO:RGD
- SMAD binding : ISO:RGD
- transforming growth factor beta receptor binding : IBA:GO_Central
|
| GO - Biological process |
- activation of MAPK activity : ISO:RGD
- animal organ morphogenesis : ISO:RGD
- atrioventricular valve morphogenesis : ISO:RGD
- BMP signaling pathway : IDA:RGD
- BMP signaling pathway involved in heart induction : ISO:RGD
- bone mineralization : ISO:RGD
- bone mineralization involved in bone maturation : ISO:RGD
- branching involved in ureteric bud morphogenesis : ISO:RGD
- cardiac epithelial to mesenchymal transition : ISO:RGD
- cardiac muscle cell differentiation : ISO:RGD
- cardiac muscle tissue morphogenesis : ISO:RGD
- cardiocyte differentiation : ISO:RGD
- cell development : IBA:GO_Central
- cell fate commitment : ISO:RGD
- cellular response to BMP stimulus : IEP:RGD
- cellular response to growth factor stimulus : ISO:RGD
- cellular response to mechanical stimulus : IEP:RGD
- cellular response to organic cyclic compound : ISO:RGD
- chondrocyte differentiation : ISO:RGD
- corticotropin hormone secreting cell differentiation : ISO:RGD
- embryonic heart tube anterior/posterior pattern specification : ISO:RGD
- endocardial cushion morphogenesis : ISO:RGD
- epithelial to mesenchymal transition : ISO:RGD
- heart development : ISO:RGD
- in utero embryonic development : ISO:RGD
- inflammatory response : ISO:RGD
- inner ear development : ISO:RGD
- mesenchymal cell differentiation : ISS:UniProtKB
- mesenchymal cell proliferation involved in ureteric bud development : ISO:RGD
- mesenchyme development : ISO:RGD
- negative regulation of aldosterone biosynthetic process : ISO:RGD
- negative regulation of calcium-independent cell-cell adhesion : ISO:RGD
- negative regulation of canonical Wnt signaling pathway : ISO:RGD
- negative regulation of cardiac muscle cell differentiation : ISO:RGD
- negative regulation of cell cycle : ISO:RGD
- negative regulation of cell population proliferation : ISO:RGD
- negative regulation of cortisol biosynthetic process : ISO:RGD
- negative regulation of gene expression : ISO:RGD
- negative regulation of insulin-like growth factor receptor signaling pathway : ISO:RGD
- negative regulation of steroid biosynthetic process : ISO:RGD
- negative regulation of transcription by RNA polymerase II : ISO:RGD
- negative regulation of transcription, DNA-templated : ISO:RGD
- negative regulation of Wnt signaling pathway involved in heart development : ISO:RGD
- Notch signaling pathway : ISO:RGD
- odontogenesis of dentin-containing tooth : ISO:RGD
- osteoblast differentiation : ISO:RGD
- ovulation cycle : IEP:RGD
- pathway-restricted SMAD protein phosphorylation : ISO:RGD
- pericardium development : ISO:RGD
- positive regulation of apoptotic process : ISO:RGD
- positive regulation of astrocyte differentiation : ISO:RGD
- positive regulation of bone mineralization : ISO:RGD
- positive regulation of cartilage development : ISO:RGD
- positive regulation of cell differentiation : ISO:RGD
- positive regulation of cell migration : ISO:RGD
- positive regulation of endothelial cell proliferation : ISO:RGD
- positive regulation of epithelial to mesenchymal transition : ISO:RGD
- positive regulation of ERK1 and ERK2 cascade : ISO:RGD
- positive regulation of fat cell differentiation : ISO:RGD
- positive regulation of gene expression : ISO:RGD
- positive regulation of MAPK cascade : ISO:RGD
- positive regulation of neurogenesis : IDA:MGI
- positive regulation of neuron differentiation : ISO:RGD
- positive regulation of odontogenesis : ISO:RGD
- positive regulation of ossification : ISO:RGD
- positive regulation of osteoblast differentiation : ISO:RGD
- positive regulation of osteoblast proliferation : ISO:RGD
- positive regulation of p38MAPK cascade : ISO:RGD
- positive regulation of pathway-restricted SMAD protein phosphorylation : ISS:UniProtKB
- positive regulation of phosphatase activity : ISO:RGD
- positive regulation of pri-miRNA transcription by RNA polymerase II : ISO:RGD
- positive regulation of protein binding : ISO:RGD
- positive regulation of protein phosphorylation : ISO:RGD
- positive regulation of transcription by RNA polymerase II : IDA:MGI
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus : ISO:RGD
- positive regulation of transcription, DNA-templated : ISO:RGD
- positive regulation of Wnt signaling pathway : ISO:RGD
- positive regulation of Wnt signaling pathway by BMP signaling pathway : ISO:RGD
- protein destabilization : ISO:RGD
- protein phosphorylation : ISO:RGD
- proteoglycan metabolic process : ISO:RGD
- regulation of apoptotic process : IBA:GO_Central
- regulation of MAPK cascade : IBA:GO_Central
- regulation of odontogenesis of dentin-containing tooth : ISO:RGD
- regulation of transcription, DNA-templated : ISO:RGD
- response to bacterium : ISO:RGD
- response to hypoxia : ISO:RGD
- response to mechanical stimulus : IEP:RGD
- response to retinoic acid : IEP:RGD
- SMAD protein signal transduction : ISS:UniProtKB
- telencephalon development : ISO:RGD
- telencephalon regionalization : ISO:RGD
- thyroid-stimulating hormone-secreting cell differentiation : ISO:RGD
|