Annexin A6 (P48037)

Uniprot ID P48037
Protein Name Annexin A6
Gene Name Anxa6
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
GO - Molecular function
  • actin filament binding : IBA:GO_Central
  • calcium channel activity : IBA:GO_Central
  • calcium ion binding : IEA:InterPro
  • calcium-dependent phospholipid binding : IDA:RGD
  • calcium-dependent protein binding : ISO:RGD
  • cholesterol binding : ISO:RGD
  • chondroitin sulfate binding : IBA:GO_Central
  • GTP binding : ISO:RGD
  • ligand-gated ion channel activity : ISO:RGD
  • lipid binding : ISO:RGD
  • phosphatidylserine binding : IBA:GO_Central
  • protein homodimerization activity : ISO:RGD
  • protein-containing complex binding : IPI:RGD
GO - Biological process
  • apoptotic signaling pathway : ISO:RGD
  • calcium ion transport : ISO:RGD
  • growth plate cartilage chondrocyte differentiation : IBA:GO_Central
  • ion transmembrane transport : ISO:RGD
  • mitochondrial calcium ion homeostasis : ISO:RGD
  • negative regulation of sequestering of calcium ion : IBA:GO_Central
  • neural crest cell migration : IBA:GO_Central
  • plasma membrane repair : IBA:GO_Central
  • protein homooligomerization : ISO:RGD
  • regulation of muscle contraction : ISO:RGD
  • secretion : TAS:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.