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P47942

Dihydropyrimidinase-related protein 2 (P47942)

Uniprot ID P47942
Protein Name Dihydropyrimidinase-related protein 2
Gene Name Dpysl2
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis (By similarity). .
GO - Molecular function
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides : IBA:GO_Central
  • identical protein binding : ISO:RGD
  • microtubule binding : IEA:InterPro
  • protein kinase binding : ISO:RGD
GO - Biological process
  • axon guidance : IEA:InterPro
  • brain development : IEP:RGD
  • cytoskeleton organization : ISS:UniProtKB
  • endocytosis : ISS:UniProtKB
  • olfactory bulb development : IEP:RGD
  • positive regulation of glutamate secretion : IDA:RGD
  • regulation of axon extension : NAS:RGD
  • regulation of neuron differentiation : IMP:RGD
  • regulation of neuron projection development : ISO:RGD
  • response to amphetamine : IEP:RGD
  • response to cocaine : IEP:RGD
  • response to drug : IEP:RGD
  • spinal cord development : IEP:RGD
  • synaptic vesicle transport : IDA:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.