Nardilysin (P47245)

Uniprot ID P47245
Protein Name Nardilysin
Gene Name Nrdc
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • metalloendopeptidase activity : IEA:InterPro
  • peptidase activity : IDA:MGI
GO - Biological process
  • negative regulation of cold-induced thermogenesis : ISS:YuBioLab
  • peptide catabolic process : IBA:GO_Central
  • positive regulation of membrane protein ectodomain proteolysis : ISO:RGD
  • proteolysis involved in cellular protein catabolic process : IBA:GO_Central
  • regulation of endopeptidase activity : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.