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P47199

Quinone oxidoreductase (P47199)

Uniprot ID P47199
Protein Name Quinone oxidoreductase
Gene Name Cryz
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (5) Interactions
Signal peptide(a) N Secretome P(b) 0.719
Function Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). .
GO - Molecular function
  • mRNA 3'-UTR binding : ISS:UniProtKB
  • NADP binding : ISO:MGI
  • NADPH binding : ISS:UniProtKB
  • NADPH : ISS:UniProtKB
  • zinc ion binding : IEA:InterPro
GO - Biological process
  • protein homotetramerization : ISO:MGI
  • xenobiotic catabolic process : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.