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P46109

Crk-like protein (P46109)

Uniprot ID P46109
Protein Name Crk-like protein
Gene Name CRKL
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.71
Function May mediate the transduction of intracellular signals.
GO - Molecular function
  • cadherin binding : HDA:BHF-UCL
  • identical protein binding : IPI:IntAct
  • phosphotyrosine residue binding : IPI:CAFA
  • RNA binding : HDA:UniProtKB
  • SH3/SH2 adaptor activity : TAS:ProtInc
GO - Biological process
  • activation of MAPKK activity : TAS:Reactome
  • animal organ morphogenesis : IEA:Ensembl
  • anterior/posterior pattern specification : IEA:Ensembl
  • blood vessel development : IEA:Ensembl
  • cytokine-mediated signaling pathway : TAS:Reactome
  • heart development : IEA:Ensembl
  • intracellular signal transduction : TAS:ProtInc
  • JNK cascade : TAS:ProtInc
  • parathyroid gland development : IEA:Ensembl
  • positive regulation of cell proliferation : IMP:CACAO
  • positive regulation of substrate adhesion-dependent cell spreading : IMP:UniProtKB
  • Ras protein signal transduction : TAS:ProtInc
  • thymus development : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.