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P45591

Cofilin-2 (P45591)

Uniprot ID P45591
Protein Name Cofilin-2
Gene Name Cfl2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.866
Function Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G-and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. .
GO - Molecular function
  • actin filament binding : IDA:UniProtKB
GO - Biological process
  • actin filament depolymerization : IDA:UniProtKB
  • actin filament fragmentation : IDA:UniProtKB
  • actin filament organization : IMP:MGI
  • muscle cell cellular homeostasis : IMP:MGI
  • positive regulation of actin filament depolymerization : ISO:MGI
  • sarcomere organization : IMP:MGI
  • skeletal muscle tissue development : IMP:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.